Title: The Connection between Childhood Sleep Apnea and ADHD: A Comprehensive Review

Author(s): Mary Ibrahim, DMD

Email: mibrahim@mercy.com

Introduction:  Childhood sleep apnea and Attention Deficit Hyperactivity Disorder (ADHD) are prevalent pediatric conditions that can significantly impact a child’s cognitive, behavioral, and emotional development. Sleep apnea in children is characterized by repeated interruptions in breathing due to recurrent partial or complete obstruction of the upper airway during sleep. This then results in fragmented sleep patterns and reduced oxygenation levels, and compromised sleep quality. ADHD is a neurodevelopmental disorder marked by persistent patterns of inattention, hyperactivity, and impulsivity. This abstract explores the intricate relationship between these two disorders, aiming to elucidate their mutual influences and potential therapeutic implications.

Discussion of Literature ReviewBetween 20% and 50% of the pediatric and adolescent population may have a sleep disorder (insomnia, periodic limb movement disorder, restless leg syndrome, sleep related breathing disorder, and obstructive sleep apnea), but because sleep disorders in this group are hard to catch, they often go undiagnosed. Daytime symptoms of insufficient quality sleep in children can present as ADHD and ADD, hyperactivity, behavioral issues and irritability, neurocognitive impairment, and poor school performance. Sleep-disordered breathing, particularly obstructive sleep apnea (OSA), is increasingly recognized as a significant concern in pediatric populations. OSA disrupts normal sleep architecture, leading to fragmented sleep patterns, intermittent hypoxemia, and sleep fragmentation. OSA can be due to obesity, enlarged adenoids, large tongue, narrow palate, constricted maxilla, and presence of the lingual frenum. While traditionally associated with nocturnal symptoms such as snoring and observed apneas, emerging evidence suggests a bidirectional relationship between OSA and daytime behavioral problems, including ADHD symptoms. ADHD is one of the most prevalent and intensively studied childhood developmental disorders and affects a large portion of the pediatric population. The overlap between ADHD and sleep disturbances is well-documented, with studies indicating a higher prevalence of sleep problems among children with ADHD. Conversely, recent research has highlighted the association between untreated OSA and ADHD-like symptoms, suggesting that sleep disturbances may contribute to the manifestation and exacerbation of ADHD behaviors. Research has shown that the removal of adenoids has helped lower OSA which reduces the symptoms of ADHD. Treatment strategies for children with comorbid sleep apnea and ADHD should address both conditions concurrently, aiming to improve sleep quality, cognitive function, and behavioral regulation. Interventions may include adenotonsillectomy for obstructive sleep apnea, behavioral therapy for ADHD symptoms, and pharmacotherapy when indicated.

Conclusion:  By understanding the complex interplay between these conditions and adopting a comprehensive approach to assessment and treatment, clinicians can improve outcomes and enhance the quality of life for children affected by this comorbidity. Clinicians can do so by integrating input from pediatricians, sleep specialists, and mental health professionals to address the complex needs of affected children. Further research is needed to elucidate the precise nature of this relationship and to develop tailored interventions that address the unique needs of individuals with comorbid sleep apnea and ADHD. By advancing our understanding of this intersection, clinicians can enhance diagnostic accuracy, treatment efficacy, and overall quality of life for affected individuals.